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When and How to test for Syphilis

Syphilis Test

Phew. Finally found the time to sit down and pen this long awaited entry. I have been getting questions about Syphilis testing and would like to set the record straight.

Syphilis Symptoms

First of all a few basic facts. Syphilis is a bacteria. It is transmitted via direct skin contact with contagious Syphilitic lesions. What are considered contagious Syphilitic lesions you say? Well, they are ulcers caused by Syphilis (known as a Chancres) and the skin rash that occurs in secondary Syphilis. The ulcers are generally single and painless (except in HIV positive patients where the ulcers can be multiple and painful). They can appear anytime between 9 to 90 days post infection. Most commonly they appear at about 4 weeks post infection. The ulcers are found at the site of bacterial entry. So they can be anywhere but they are most frequently found in the anogenital region. The rash caused by secondary Syphilis is called the Great Imitator because it can look like any rash. It appears 3 to 6 weeks after the initial Syphilitic ulcer (Chancre) has subsided. Since it can look like anything, it is hard to differentiate from other rashes (eg eczema). It is usually a macula-papular rash that involves the trunk more than the limbs and also involves the palms and soles.

At this point some of you are asking ‘If what you say is true, then Syphilis is not necessarily sexually transmitted.’ To that I say ‘You are absolutely right.’ There was a user on the forum (www.askdrtan.com) who caught Syphilis from her client. She is a masseuse. Direct skin contact with infectious lesions remember?

Syphilis Stages

Next I want to clear up some technical terms. Often people throw words at me like ‘Early Primary Syphilis’ and ‘Latent Secondary Syphilis’. This shows that there is a lot of confusion in the terminology out there. So let’s set the record straight.

There are 2 stages of Syphilis: Early and Late. The definition of early Syphilis VARIES depending on which guidelines you read. According to the US CDC, if the Syphilis infection was within the past 1 year, it is considered Early Syphilis. According to the WHO it is 2 years. Why does this matter? It determines what treatment a patient gets. Early Sypphilis requires less medicines than Late Syphilis. So far confusing enough? It gets worse.

Early Syphilis is divided into 3 clinical stages. Primary Syphilis, Secondary Syphilis and Latent Syphilis (also known as Early Latent Syphilis). The stages are characterized as such: Primary Syphilis – presence of Chancre, Secondary Syphlis – presence of rash, Latent Syphilis – no symptoms.

Late Syphilis is divided into 2 clinical stages. Tertiary Syphilis and Latent Syphilis (also known as Late Latent Syphilis). The stages are characterized as such: Tertiary Syphilis – End organ involvement including aneurysms, Latent Syphilis – no symptoms.

There are 2 other types of Syphilis we will not be discussing in this post and they are Neuro-Syphilis (Syphilis involving the nervous system) and Syphilis in the Newborn.

Syphilis Tests

Remember we said Syphilis is a bacteria? To be more precise, Syphilis is the disease caused by a bacteria and this bacteria is called Treponema Pallidum. The special thing about T. Pallidum is that it cannot be cultured. In other words, you cannot grow it in a dish. The only way to prove it is there is either to see the live bacteria directly or by using indirect evidence of its presence (something known as serology tests which are essentially blood tests).

To see the live bacteria you first need an active lesion. Next, you need a skilled person to sample bacteria from the lesion. Next you need special equipment and specially trained medical professionals to use this special equipment to look for the bacteria. Because the case load of Syphilis for most countries is rather low, most labs either do not have the equipment or the training. Also, because if the high rate of false negatives from these tests, patients suspected of Syphilis are required to follow up with serology testing anyway. In other words, these tests are rather useless except in very specific settings.

Serology tests are the mainstay of diagnosing Syphilis. There are basically 2 types of serology tests: Treponemal Tests and Non-Treponemal tests. There are many types of Treponemal Tests (eg TPHA, FTA-Abs etc). There are also many types of Non-Treponemal tests (VDRL, RPR, HEAT etc). For ease of discussion we will consider all Treponemal tests the same and all Non-Treponemal tests the same.

The one very important thing to remember is that there is no such thing as one perfect ‘most accurate’ test for Syphilis. This is what most people look for and it is really just chasing a rainbow.

Treponemal tests are very good at screening for Syphilis. They are as good as 100% accurate in diagnosing Syphilis except under 3 conditions. The first is very early Syphilis. When I say very early I mean less than 12 weeks from the date of infection. Although Treponemal tests are as good as conclusive at 4 weeks, the recommendation is still to retest at 12 weeks. The second is very late latent Syphilis. How late? Nobody knows. The accuracy of Treponemal tests is late latent Syphilis drops from 100% to 97% over several years. The third and last condition under which Treponemal tests are of no use is if a person has been previously infected with Syphilis. Even if this person has been treated successfully, the Treponemal test will still remain positive. So there is no way to know if this person has been re-infected or not using Treponemal tests.

Non-Treponemal tests are often used for screening of Syphilis in places where the prevalence of Syphilis is relatively high. This is because of the third reason given in the preceding paragraph. (Also because it is cheaper). So you would notice that European Guidelines recommend using Treponemal tests for screening and most Asian guidelines recommend using Non-Treponemal tests. On the whole, Non-Treponemal tests are LESS ACCURATE than Treponemal tests when used for screenig of Syphilis. They are however useful under 2 conditions. The first is when a person has been previously infected with Syphilis and we need to find out if he or she has been re-infected or not. The second is for monitoring of treatment success or failure.

So remember we said there is no one perfect test for screening of Syphilis? The trick is to do both a Treponemal as well as a Non-Treponemal test for patients. That is ideal.

If a patient has never had Syphilis before, which would be the majority of readers here, and you HAD to choose one test, than the Treponemal test is better. Remember to always test at 4 weeks and retest at 12 weeks.

I hope that added some clarity to Syphilis testing.

I would like to end off on the note that nothing in Medicine is straightforward. Just when you think you had a handle on Syphilis testing, let me tell you this: All the above serology tests mentioned above will also be POSITIVE if a person has any of the Non-Syphilitic Treponemal Diseases. You didn’t think Syphilis was an only child did you? There are other bacteria under the Treponemal family which will all test positive using the exact same tests as we use to diagnose Syphilis.

So after all this discussion, we come back to square one. The same usual boring advice I give everyone.

Do not try to be your own doctor by reading the internet. If you want to know whether you have been infected with Syphilis or not, please Our Doctors trained in such matters and heed his advice.
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About Dr. Tan
Dr. Tan graduated from the National University of Singapore in 2001. His residency was in the two largest public hospitals in Singapore; Tan Tock Seng Hospital and Singapore General Hospital.

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112 Comments

  1. Hi,
    Had a massage more than a month ago. No sexual contact but it’s a gay massage parlour. Noticed some red spots on my back last week, they probably are pimples. Should i go for a checkup for syphilis for clarity of mind and what’s the usual cost to do a test?

    Thanks.

  2. John Doe

    Hello I am freaking out here and I am very scared. I for an rpr test done for syphllis at 17 days past exposure. It came back as non-reactive. It was oral sex both giving and recieiving. I had an oral exam of my thoart and it checked out ok. My partner went to the dr, got tested and came back negative on Oct 10th. We fooled around on 9/23/2016 Should I still be so worried. I am showing no syptoymns and now it has been 26 days.

  3. Hai Dor..i recently had a handjob with a massage girl..am i at risk of contracting syphilis?

  4. I will be visiting SNG and would like to do perform a std test. Suspect infected with syphilis. How long does it take before test result is knows. If treatment with injection is needed how many consultations are needed ?

  5. Hi
    I’m 24 years old. I have syphylis. The doctor prescribed me doxycycline (100mg twice a day for 15 days). Before treatment I made blood tests, this is results (before treatment):
    VDRL 1/2
    FTA 1/450
    TPHA 1/5120
    FTA-ABS positive

    PS: I don’t remember any symptoms. And I finish taking doxycycycline.

    1. What stage of syphylis is?
    2. What does it mean high value TPHA 1/5120 and another are low?
    3. Whether the treatment doxycycline for 15 days will be effective in this case?

    • Stanley, please direct these questions to your doctor. We cannot give medical advice or result interpretation over the internet. All I can say is, doxycycline is a suitable treatment for syphilis, usually given for patients with penicillin allergy.

  6. Doctor I am a 35 years old married woman. 3 months ago I had a health screen and got the report recently surprised me by showing STD result that both syphilis antibody and TPHA reactive! It further indicated RPR 1:1 weak reactive. Report result describing in this way” this indicate you may have history of previous treated syphilis If this has not been known by you before see your doctor” I never know I have that and no symptom no treatment as well. So doctor what does the health screen result mean? Does that mean I confirmed had syphilis?Do I have it now ? Is that infecting to my husband now? Does my husband need do the test also? Do we both need treatment now? Appreciate your kindly advice on this. Looking forward to hearing from you urgently. Thanks.

    • Hi Vivian. Well first of all, I am very surprised that your results were just given to you without a Doctor giving you a full and proper explanation. Syphilis screening is very complicated and this is certainly not the platform to be giving you medical advice on this. It is not as straightforward as “the test is positive so you have Syphilis”. The test could be a false positive. Or maybe you do have latent Syphilis. As I said, it is too complicated to summarize here. You really should see a doctor well trained in interpreting Syphilis test results.

      • Doctor Tan, Thank you for your advising. I would like to bring my health screening report to doctors to get a detailed consultant. May I know does your clinics accept walk in consultant or shall I need make an appoinment?

  7. Hi Dr Tan,

    I had an exposure almost 2 years ago that I only recently found out about (penetrative vaginal sex, partner removed condom without my knowledge). I found out because I got tested positive for another STD and was not sexually active otherwise. The clinic I went to used the RPR to test for Syphilis but I read that the RPR could be non-reactive for late-latent syphilis, which is probably the case for a 2 year old infection. Can I trust this non-reactive RPR or what sort of testing is optimal for me? I’m really worried.

    • You are right. That is why we always use BOTH a Treponemal and Non-Treponemal test to screen for Syphilis. You should talk to your doctor about this.

  8. I had an RPR test at 7.5 weeks post exposure that came back negative, is this conclusive? I also had my hepatitis tests at 8 weeks post exposure and all came back negative, wondering if I should retake the tests as I am now 15 weeks post exposure. I got my HIV testing done at 13 weeks and it was negative, so I know I can put that to rest.

    • In my view your tests are not conclusive. Please verify this with the doctor who did the tests for you.

      • Thanks Dr Tan. Is that inconclusive for both the Syphilis and Hepatitis? I read that Hep A and C are conclusive at 6 weeks.

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