Medical Treatment for Premature Ejaculation

In this article, we will focus on the Medical Treatment options available for the treatment of Premature Ejaculation.

For other non-medical options, please read our previous article on Premature Ejaculation.

There are basically 2 types of Medicines that work well in the treatment of Premature Ejaculation. They are all effective and safe.

As with all medicines, they work better for some people than others. It is therefore important that you see Our Doctors who can give you professional advice on changing and mixing medicine types and dosages to achieve the best results for you.

Premature Ejaculation Infographic

Medicines used to treat Premature Ejaculation

1. SSRIs (Selective Serotonin Re-uptake Inhibitors)

In a nutshell, these medicines help your nerves ‘talk’ better with each other. And when they do, you get better control over when you ejaculate.

The only SSRI and really the only medicine officially indicated to treat Premature Ejaculation is Dapoxetine. It is marketed under the brand name Priligy. The usual starting dose is 30mg. It is taken 2 to 3 hours before planned sexual activity. In some patients, it can increase the duration up to 4 times the baseline. The 2 commonest side effects of this medicine are nausea and feeling sleepy. One really important fact that you have to know about Dapoxetine is that you will not experience its maximum benefit from the first pill. It usually takes up to 6 pills for you to see its maximum potential. So when you first start on this medicine, it is recommended that you take at least 1 pill per week and reach a total of 6 pills before you decide if it is working for you or not. In some instances, the dose needs to be increased to 60mg. It is also safe for Dapoxetine to be taken everyday.

All the other SSRIs are not indicated in the treatment of Premature Ejaculation. But since the delay of ejaculation is a common side effect of SSRI treatment, some doctors use these medicines for exactly this side effect. Common SSRIs used are Setraline, Paroxetine and Fluoxetine. In cases where Dapoxetine does not work well, some doctors might prescribe one of these SSRIs to be taken daily instead of just before sexual activity.

Advertisement video for Dapoxetine.

2. PDE5-Is (Phosphodiesterase 5 Inhibitors)

These medicines are well known in the treatment of Erectile Dysfunction. They are Cialis, Levitra and Viagra.

They have also been used very successfully in the treatment of Premature Ejaculation. They work particularly well if the Premature Ejaculation is a consequence of Erectile Dysfunction. Basically a guy might have problems getting hard or staying hard. So once he is hard, he pumps very vigorously so as not to lose the hardness. This of course will cause him to ejaculate sooner then her would like. In this way, Erectile Dysfunction causes Premature Ejaculation.

However, these medicines also work for Premature Ejaculation even is the patient is NOT suffering from Erectile Dysfunction. They work particularly well if given in combination with Dapoxetine. This was proven in the very famous scientific study aptly named the COUPLES study.

Aside from possibly causing flushing, heartburn and headache, these medicines are generally very safe. They are to be taken at least 15 minutes to 30 minutes before planned intercourse. The only exception is Cialis 5mg low dose once-a-day pill. This is designed to be taken everyday regardless of sexual activity.

Control in Bed!

All these medicines require a Doctor’s prescription in Singapore. You cannot buy them over the counter at a pharmacy.

All our clinics provide consultation for these medicines.

After the first consult, we would generally allow patients to continue purchasing the same medicine from the clinic without any further consultations.

Of course, if you experience any side effects with the medicines or have been prescribed new medicines please see our Doctor again for a review.

Your are welcome to visit Our Doctors at Our Clinics anytime during our opening hours.


Need more advice?

To find out more about Penile Rash or other Men’s Health issues , please visit your doctor or visit Men’s Health Clinic.

Dr. Tan and Partners @Novena (Men’s Health Clinic)


10 Sinaran Drive,
#08-31, Novena Medical Centre
Singapore 307506

+65 6397 2095

Learn more about Andrology and Infection Centre at Novena Medical Center services.


Other clinics

Come down to Our Clinics for a discussion with Our Doctors, or call our clinics for more information:

Singapore Branches


Where to find us – here

Selected clinics are open on Saturday and Sunday.


All Our Doctors are Fully Certified and Trained to conduct specialised STD Screening,  STD Testing & STD Treatment and HIV Testing.

Related Topics:

  1. Penile Discharge (Should I be Worried?)
  2. Frenulum Breve and Penile Frenulectomy
  3. Warts
  4. Molluscum
  5. HIV Symptoms
  6. Syphilis
  7. Herpes
  8. STDs General Info
  9. Premature Ejaculation
  10. Erectile Dysfunction

About Dr. Tan
Dr. Tan graduated from the National University of Singapore in 2001. His residency was in the two largest public hospitals in Singapore; Tan Tock Seng Hospital and Singapore General Hospital.

Find the profiles of our panel of doctors.


  1. Lord voldemort

    Which are the clinics with male doctors?

    • You may come down to our Robertson Walk clinic either on weekday afternoons (1-9pm) or weekends (9am-2pm) for a male doctor – it is a walk-in clinic, so no appointment is necessary. Alternatively, our Somerset and Novena clinic doctors are also male, but it is best to ring them for an appointment first.

  2. Jonathan

    How much the pill of dapoxetine?

    Can I get I think online?

    • Hi,
      We provide dapoxetine at $120 per packet. It should be prescribed by a doctor after proper consult and evaluation of symptoms and discussion of risks and benefits – so no, I do not think that you can get it online. Do drop by our clinic if you wish to discuss further.

  3. T Anand

    Hi Dr.. I’m suffering from PE. Tried Priligy, 30 mg tab work for me. However, I’m looking for permanent cure. Is there any such treatment available?

  4. Hi Dr,
    Is it true that I could take Priligy once a week with no plan sexual activity as a form of treatment? Thanks!

    • The answer to that question is equivalent to medical advice that we are not allowed to give over the internet. Officially, Priligy is indicated for use before sexual activity.

  5. hi doctor my pe very small not very hard went in bed how i can make my pe big and longer? i try many type of medicine but not use pls give advice to make bib n longer nhard

    • You are talking about penile enlargement. I am not an advocate of that. You should see your doctor to see if you actually have micro-penis. If you do, it could be due to secondary hormonal problems which may have to be addressed.

  6. stop illegal sex

    Thanks, dr. tan.

    Can u tell u did not cure I understand. But can u tell me that somebody take medicine and after completing the course become better than before.

    So far I know u need to improve the power of next medicine bcoz the previous medicine is not responding good now. Or any other doctor u know please reply just yes if u can.

    • I honestly have no idea what you are asking. If you suffer from PE please see a doctor. If you have tried a treatment that did not work, there are always alternatives. You are welcome to visit us at our clinics anytime.

  7. Hi Dr Tan ,

    Im suffering from PE . how to arrange consultation session with you ? may i know how much cost per visit ?

  8. Lakhvir singh

    I am 29 year suffering with premature ejaculation i am 5 year married . Can it be fix properly for long life ? it will better if you contact me by mail thanks.

    • I deleted your email. You really shouldn’t be posting your personal email on a public blog. There are treatments for PE but they do not offer a long term cure.

      • Hi Dr. Tan.

        This is Tan here from Kuching Sarawak. I also suffering from PE. Is it possible for you to send me PE tablets by post? Or do you have any doctor can introduce to me in Kuching?


        • We are working with a reliable online pharmacy to provide medications for our overseas patients. We will let you know once this service is ready.


  1. Medical Treatment for Premature Ejaculation | Men's Health | How to last longer ? - […] Read more… […]
  2. The Low Down on Viagra, Cialis and Levitra | Men's Health - […] 5. The Cialis 5mg once-a-day pill  has been found to be very effective in treating Premature Ejaculation when taken…
  3. Premature Ejaculation (PE) | Men's Health - […] SSRIs. Also known as Selective Serotonin Re-uptake Inhibitors. These are a class of medicines that are used to treat…