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HIV P24 Ag/Ab Test, Duo Test, Combo Test at our Clinic

Updated information on Rapid Anonymous HIV Combo test at our Clinics. 

 

Info leaflet for SD Bioline Combo Test

Info leaflet for SD Bioline Combo Test

I have been getting a lot of question with regards to the Duo test or Combo test as it is also known as.

Let’s first get some basics right:

Duo Test = Combo Test = P24 Ag/Ab test

All these terms refer to the same thing. Basically it is a test that simultaneously tests for the HIV P24 Antigen and the HIV antibody.

HIV Prevention within 72 hours of exposure (PEP) – Click Here

The HIV P24 antigen is a small piece of protein that is found on the capsule of the HIV virus. When a person is infected with HIV, these bits of protein can be found floating in the blood. The HIV P24 test is a test that detects these bits of protein. This test was first developed as a HIV screening test but rapidly ran out of favor due to the development of more advanced NAAT tests. (For more details on NAAT testing please read: http://www.drtanandpartners.com/nucleic-acid-amplification-testing-naat/)The window period for P24 testing is also very small. This test alone is only accurate for between 3 and 6 weeks post exposure. So it is a test with very limited applications unless combined with the HIV antibody test. The presence of P24 Antigens in the blood indicates a recent HIV infection.

Click here for details on getting the Combo test at our Clinics

We all already know that the HIV antibody test becomes quite reliable at 4 weeks and as good as conclusive at 6 weeks. Although most health authorities still recommend a 3 months window period. So putting these 2 tests together gives you a very powerful tool to diagnose HIV infection in as little as 3 weeks. Personally I prefer to conduct the Combo test at 4 weeks because I believe that is when the level of P24 antigen peaks in the blood giving us maximum accuracy.

In our clinic, we use the SD Bioline Rapid HIV Combo Test 2.0. It is a rapid test that takes only 20 minutes for us to get results. We are also approved to conduct this test as part of the Anonymous HIV testing Program.

The test is conducted very much like the HIV antibody test. All we need is blood from a finger prick. (For more details on Anonymous HIV Testing at our clinic please read: http://www.drtanandpartners.com/anonymous-hiv-testing-at-our-clinic/)

SD Bioline HIV Combo Test showing a positive result (2 red bars)

SD Bioline HIV Combo Test showing a positive result (2 red bars)

 

 

 

 

 

 

 

 

 

SD Bioline Combo HIV test showing a positive result. Note the test line is very faint. This could be due to a very recent HIV infection or the test could be false positive (1% chance).

SD Bioline Combo HIV test showing a positive result. Note the test line is very faint. This could be due to a very recent HIV infection or the test could be false positive (1% chance).

 

 

 

 

 

 

 

 

 

Multicentre clinical trials have shown 100% sensitivity and more than 99% specificity.

This kit has been registered with Singapore’s Health Science Authority (HSA).

So the Combo Test has many advantages including:

1. Earlier detection of HIV infection.

2. Rapid (20 minutes)

3. Anonymous

The only problem is that it costs more. At our clinic is costs $200 ($214 with GST).

Click on the picture for the latest information on the HIV testing Window Period

Click on the picture for the latest information on the HIV testing Window Period

 

 

 

 

 

 

 

 

 

Click here for HIV Testing FAQ

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If you have any questions, visit our free online forum on sexual health, HIV and STDs.

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If you need a HIV test visit Our Clinics anytime during our opening hours. You do not need an appointment.

We are now open on weekends.

Find out more about Anonymous HIV testing at our clinics.

Can’t wait for 3 months to find out? Find out more about Anonymous Rapid HIV Combo test at our clinics.

If you had a high risk exposure to HIV within the past 72 hours, you can take medicines to reduce your risk of actually contracting HIV. Find out more on HIV PEP Treatment.

We have 3 locations conveniently located at Robertson Walk and Bencoolen Street and Novena Medical Center.

We are Open on Saturdays and Sundays.

Click Here for Contact Details, Address and Opening Times.

Related Topics:

Anonymous HIV testing at our Clinics

HIV – Understanding the Window Period

Cost of HIV/STD tests at our Clinics

Condom Broke

Getting HIV from Oral Sex

More on HIV symptoms

How long can HIV live outside the body?

 

Consultation $20.00-80.00
Rapid test only $20.00
(not inclusive of test)
8am – 5pm $60.00
5pm – 9pm $80.00
STD screening
Standard HIV, Syphilis, Hepatitis B/C, Herpes Simplex Virus Type I and II $ 200.00
Male
Urethritis
Urine – Chlamydia and Gonorrhoea PCR, Monilia, Trichomonas, NSU, Mycoplasma, Ureaplasma, Urine Culture, Candida $ 280.00
Female
Urethritis and Vaginitis
Vaginal Swab – Chlamydia and Gonorrhoea PCR, Monilia, Trichomonas PCR, Gardnerella PCR, Candida PCR, Group B StrepNSU, Mycoplasma, Ureaplasma, Direct Microscopy, Candida, Vaginal swab culture $ 345.00
Comprehensive (Male) Blood – Syphilis, Hepatitis B/C, Herpes Simplex Virus Type I and II

Urine – Chlamydia and Gonorrhoea PCR, Monilia, Trichomonas, NSU, Mycoplasma, Ureaplasma, Urine Culture, Candida

$ 390.00
Comprehensive (Female) Blood – Syphilis, Hepatitis B/C, Herpes Simplex Virus Type I and II

Vaginal Swab – Chlamydia and Gonorrhoea PCR, Monilia, Trichomonas PCR, Gardnerella PCR, Candida PCR, Group B StrepNSU, Mycoplasma, Ureaplasma, Direct Microscopy, Candida, Vaginal swab culture

$ 525.00
Individual STD Tests
Determine Syphilis test Rapid Syphilis Test $ 50.00
Determine Hepatitis B Test Rapid Hepatitis B Test $ 50.00
Herpes Simplex Virus PCR Herpes Simplex Virus Polymerase Chain Reaction (PCR) Test $ 190.00
Chlamydia and Gonoccocal PCR Chlamydia and Gonorrhea
Herpes Simplex Virus Type I IgG Antibody Herpes Type 1 $ 40.00
Herpes Simplex Virus Type II IgG Antibody Herpes Type 2 $ 40.00
Non-Specific Urethritis (NSU) Culture Mycoplasma, Ureaplasma $ 118.00
HIV test
HIV RNA/DNA Polymerase Chain Reaction (PCR) Test $600
Add $100 for expedited results
Rapid Fingerprick Blood HIV-1/2 P24 Antigen/Antibody Combo (HIV Duo Test) (4th generation!) $ 150.00
Rapid Oral Saliva HIV-1/2 Antibody Test (Oraquick) $ 50.00
Rapid Fingerprick Blood HIV-1/2 Antibody Test (Determine) $ 50.00
PEP $2000 – $2200

About Dr. Tan
Dr. Tan graduated from the National University of Singapore in 2001. His residency was in the two largest public hospitals in Singapore; Tan Tock Seng Hospital and Singapore General Hospital.

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1,141 Comments

  1. Sebastian Rpo

    Dr., Thank you for the support. I tell him that I do a test architect combo abbot to the exact 28 days and gave me no, but I wanted you to get an queries about this and to end this episode of my life;

    1.Is this kind of combo conclusive test at 28 days?
    2.I call attention to a response of this page is:
    Have there been any occasions in which you or indeed fellow colleagues of yours have found a 28 day negative turn positive?
    R/: Yes – but only with people who were clinically ill at the time, had very high risk exposures (with others who had recently become infected and so their infectiousness was very high) and so they clinically generated a high degree of concern on our part. I should say though that there are tiny numbers of these – perhaps 3 in 5 years and with the numbers of tests we do per year this is miniscule. In someone such as yourself where even if you had had vaginal unprotected sex with a female of unknown status I would regard the result as certain

    3. The question dealing with this is that if there is possibility to change the result in people suffering from cancer or other issues? I’m healthy I would have no problem?

    4. For a test to be conclusive at day 28 no matter what level of risk you have taken, what matters is that the test is negative.?

    5. This is another of the paragraph that caught my attention

    From the Freedomhealth point of view, using as described above the combined knowledge and experience of the team we regard the HIV DUO test as a conclusive HIV test at 28 days or beyond in almost all circumstances. In situations where a patient has had an exceptionally high level of HIV exposure and has symptoms which we might in our expert opinion regard as suggestive of an acute HIV infection, we will encourage the patient to re-test at an appropriate interval which we will decide with the patient. However, it is almost always the case that a negative HIV DUO test at 28 days or more will be conclusive and will not need repeating.

    6.I think this points to what you call if there is a human error that through must be another risk situation and have to repeat the test is the same as the 28 days and would be the antigen and igm?

    • Sebastian Rpo

      Dr excuse my bad English , the test gave negative and these are the questions of a product called Freedomhealth about the test at 28 days .

  2. I had protected vaginal sex with one highclass escort in India and kissing. I do not have open shores and cuts. Is there a risk of HIV or other STD .Do i need to go through tests than which tests.Please guide me.

    • I’m sorry. This forum is not for dispensing medical advice. Please see your doctor for what tests you need to do. All I can say is that you are at risk of HIV but the risk is very low. You are also at risk of other STDs.

  3. Sebastian Rpo

    Dr data to argue that combo is conclusive evidence is that IgM are in maximum blood at 24 days and p24 appears to 7 days , with this the 28th already a conclusive result . What is the reason you believe that BASH STATEMENT put a period of 8 weeks?

    • I think the recommendation to retest at 8 weeks is more to rule out human error than because of a concern of the accuracy of the test itself. Or maybe it is just for a “just in case so that we can legally cover our asses” reason. I’m not sure.

  4. Hello again the link works but the file u want to read is downloaded to your Downloads folder.For the link that u have sent to me i disearee about the holes in condoms.The holes in condoms does not exist,if they break they break obviously and u understand that u are in risk and should test.My condom has broken with my girlfriend and i have seen it how it breaks.Holes in condom does not exist and water test is in my opinion Bullshit sorry for this word.also one’s again the link : http://www.bashh.org/documents/BASHH-EAGA%20statement%20on%20HIV%20WP%20(Nov%20%2014).docx

    • Sebastian Rpo

      Here is the text for the link does not work:

      BASHH/EAGA statement on HIV window period

      November 2014

      HIV testing using the latest (fourth generation) tests is recommended in the BHIVA / BASHH / BIS UK guidelines for HIV testing (2008). These assays test for HIV antibodies and p24 antigen simultaneously. A fourth generation HIV test on a venous blood sample performed in a laboratory will detect the great majority of individuals who have been infected with HIV at 4 weeks after specific exposure.

      Patients attending for HIV testing who identify a specific risk occurring less than 4 weeks previously should not be made to wait before HIV testing as doing so may miss an opportunity to diagnose HIV infection (and in particular acute HIV infection during which a person is highly infectious). They should be offered a fourth generation laboratory HIV test and be advised to repeat it when 4 weeks have elapsed from the time of the last exposure.

      A negative result on a fourth generation test performed at 4 weeks post-exposure is highly likely to exclude HIV infection. A further test at 8 weeks post-exposure need only be considered following an event assessed as carrying a high risk of infection.

      Patients at ongoing risk of HIV infection should be advised to retest at regular intervals.

      Patients should be advised to have tests for other sexually transmitted infections in line with advice on window periods for those infections (see BASHH guidelines at: http://www.bashh.org ).

      Dr Keith Radcliffe – Chair, BASHH Clinical Effectiveness Group
      Dr Laura Waters – Chair, BASHH HIV Special Interest Group
      Prof Brian Gazzard – Chair, Expert Advisory Group on AIDS
      Dr Jan Clarke – President, British Association for Sexual Health and HIV

    • LOL! I think NIAID will be very upset you called bullshit on their study!

  5. Camilo Rpo

    Dr I value what you do for people helping them with this issue, first of all want to thank.
    Dr long before I was finding out when he did not know of your page, and I found something that I doubt genre and is a statement on BASH STATEMENT HIV window period 15th march 2010 where he said that despite the combo was very good at 28 days had to be repeated at 3 months, I wrote to a lab and they said it was because some subtypes of HIV and could not identify the so it was good to repeat at 3 months the 3rd generation, I want to ask if they have knowledge and this test has included all subtypes and me can do with ease the 28th since I live in Colombia and here make HIV architect combo Abbot?

    • Camilo Rpo

      It was already updated the text to November 2014, and says :A further test at 8 weeks post-exposure need only be considered following an event assessed as carrying a high risk of infection. That is for them a high risk referred to , that would apply in this case . if all risks are equal if they refer or if one was with hiv positive person identified , but if you do not know ?

      • I find the lab statement rather confusing. If there are subtypes of HIV that cannot be identified on tests, then why would repeating the test at 3 months make any difference? If the subtypes cannot be identified that logically they cannot be identified no matter how long you wait to take the test. I also think the recommendation to test at 8 weeks for a high risk infection is based more on the “just in case someone somewhere cocks it up” mantra rather than on the accuracy of the test itself.

  6. Sebastian Rpo

    Dr I value what you do for people helping them with this issue, first of all want to thank.
    Dr long before I was finding out when he did not know of your page, and I found something that I doubt genre and is a statement on BASH STATEMENT HIV window period 15th march 2010 where he said that despite the combo was very good at 28 days had to be repeated at 3 months, I wrote to a lab and they said it was because some subtypes of HIV and could not identify the so it was good to repeat at 3 months the 3rd generation, I want to ask if they have knowledge and this test has included all subtypes and me can do with ease the 28th since I live in Colombia and here make HIV architect combo Abbot?

    • BASH STATEMENT HIV WINDOW PERIOD has changed NOV 2014 from 12 weeks to 8 weeks ;)

      • Thank you for sharing. Can you put the reference link here please? Thanks!

        • http://www.bashh.org/documents/BASHH-EAGA%20statement%20on%20HIV%20WP%20(Nov%20%2014).docx .This is the link ;) i tested with a DUO after 10 weeks post my last exposure negative 0.05(cutoff:0.25) and i had over 2 years lot of protected oral and protected sex.Also Condoms works when use consistently

          • And HIV cannot get through Latex,no way no how.For Chris’s sake always use a condom consistently for oral and vaginal and if u don’t have any breakage or slip,u can be confident that ur test will become negative.Peace all of you

          • I completely agree that everyone should use condoms correctly and consistently. However, there have been several studies to suggest that condoms may not be absolutely 100% effective. For example this report released in 2001 (http://www.niaid.nih.gov/about/organization/dmid/documents/condomreport.pdf) on page 14 it makes the statement “Overall, Davis and Weller estimated that condoms provided an 85% reduction in HIV/AIDS transmission risk when infection rates were compared in always versus never users.” So just let me say that I agree with you in that everyone should use condoms and based on the statistics, everyone who uses condoms correctly and consistently should not be worried just like you said. However, I would like to add that even if you use condoms all the time, it would be still prudent for you to get a HIV test every so often. Again, thank you for sharing.

          • Thank you very much for sharing. Unfortunately, for some reason, the link is not working. If it is not too much trouble could you put the link up again? I really appreciate this sharing of information. We can all learn much more about HIV.

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