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HIV P24 Ag/Ab Test, Duo Test, Combo Test at our Clinic

Updated information on Rapid Anonymous HIV Combo test at our Clinics. 

 

Info leaflet for SD Bioline Combo Test

Info leaflet for SD Bioline Combo Test

I have been getting a lot of question with regards to the Duo test or Combo test as it is also known as.

Let’s first get some basics right:

Duo Test = Combo Test = P24 Ag/Ab test

All these terms refer to the same thing. Basically it is a test that simultaneously tests for the HIV P24 Antigen and the HIV antibody.

HIV Prevention within 72 hours of exposure (PEP) – Click Here

The HIV P24 antigen is a small piece of protein that is found on the capsule of the HIV virus. When a person is infected with HIV, these bits of protein can be found floating in the blood. The HIV P24 test is a test that detects these bits of protein. This test was first developed as a HIV screening test but rapidly ran out of favor due to the development of more advanced NAAT tests. (For more details on NAAT testing please read: http://www.drtanandpartners.com/nucleic-acid-amplification-testing-naat/)The window period for P24 testing is also very small. This test alone is only accurate for between 3 and 6 weeks post exposure. So it is a test with very limited applications unless combined with the HIV antibody test. The presence of P24 Antigens in the blood indicates a recent HIV infection.

Click here for details on getting the Combo test at our Clinics

We all already know that the HIV antibody test becomes quite reliable at 4 weeks and as good as conclusive at 6 weeks. Although most health authorities still recommend a 3 months window period. So putting these 2 tests together gives you a very powerful tool to diagnose HIV infection in as little as 3 weeks. Personally I prefer to conduct the Combo test at 4 weeks because I believe that is when the level of P24 antigen peaks in the blood giving us maximum accuracy.

In our clinic, we use the SD Bioline Rapid HIV Combo Test 2.0. It is a rapid test that takes only 20 minutes for us to get results. We are also approved to conduct this test as part of the Anonymous HIV testing Program.

The test is conducted very much like the HIV antibody test. All we need is blood from a finger prick. (For more details on Anonymous HIV Testing at our clinic please read: http://www.drtanandpartners.com/anonymous-hiv-testing-at-our-clinic/)

SD Bioline HIV Combo Test showing a positive result (2 red bars)

SD Bioline HIV Combo Test showing a positive result (2 red bars)

 

 

 

 

 

 

 

 

 

SD Bioline Combo HIV test showing a positive result. Note the test line is very faint. This could be due to a very recent HIV infection or the test could be false positive (1% chance).

SD Bioline Combo HIV test showing a positive result. Note the test line is very faint. This could be due to a very recent HIV infection or the test could be false positive (1% chance).

 

 

 

 

 

 

 

 

 

Multicentre clinical trials have shown 100% sensitivity and more than 99% specificity.

This kit has been registered with Singapore’s Health Science Authority (HSA).

So the Combo Test has many advantages including:

1. Earlier detection of HIV infection.

2. Rapid (20 minutes)

3. Anonymous

The only problem is that it costs more. At our clinic is costs $200 ($214 with GST).

Click on the picture for the latest information on the HIV testing Window Period

Click on the picture for the latest information on the HIV testing Window Period

 

 

 

 

 

 

 

 

 

Click here for HIV Testing FAQ

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If you need a HIV test visit Our Clinics anytime during our opening hours. You do not need an appointment.

We are now open on weekends.

Find out more about Anonymous HIV testing at our clinics.

Can’t wait for 3 months to find out? Find out more about Anonymous Rapid HIV Combo test at our clinics.

If you had a high risk exposure to HIV within the past 72 hours, you can take medicines to reduce your risk of actually contracting HIV. Find out more on HIV PEP Treatment.

We have 3 locations conveniently located at Robertson Walk and Bencoolen Street and Novena Medical Center.

We are Open on Saturdays and Sundays.

Click Here for Contact Details, Address and Opening Times.

Related Topics:

Anonymous HIV testing at our Clinics

HIV – Understanding the Window Period

Cost of HIV/STD tests at our Clinics

Condom Broke

Getting HIV from Oral Sex

More on HIV symptoms

How long can HIV live outside the body?

About Dr. Tan
Dr. Tan graduated from the National University of Singapore in 2001. His residency was in the two largest public hospitals in Singapore; Tan Tock Seng Hospital and Singapore General Hospital.

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1,012 Comments

  1. Dear doc,

    I got protected sex with legal sex worker last month. I’ve tested HIV P24 Ag/Ab Test, Duo Test, Combo for 2 times, 21 days and 28 days and both are negative.

    Should i retest on the third month?

    In singapore is there any case like false-negative on the 28 days?

  2. hello doctor tan
    my question is also same but i am giving u full description of duo test
    check the link http://www.regentstreetclinic.co/hiv-aidsMEDIA/PosterHIVAIDS.jpg
    The duo test is exactly similar to this but not the same.
    there is written on that.
    C
    hiv1
    hiv2
    and my blood line came on c that means negative am i rite.
    now my concern is all hiv duo test is conclusive plz relpy

    • Dude, honestly man. I really do not understand what you mean by “The duo test is exactly similar to this but not the same”. How can it be exactly similar but not the same? So is it the same or not?

  3. Hi Dr, i had sexual without condom at 14th Sep. The partner is working at massage centre. After 1 week+27days+31days i get a antigen and antibody combo test for HIV1/2 done, all the resulf show is non-reactive. i very worry about that..pls help me Dr.

  4. confused

    hi doc
    i had foreplay with sex worker smoching and suckinh breast i had cut in my mouth
    i tested after 22day duo test hiv1/2 came negative
    doctor said u dont need any futher test
    it is conclusive

  5. Dear Dr. Tan
    how accurate and conclusive is combo test at 34 weeks = 239 days post exposure?

    Thank you

  6. Hi doc

  7. Hi drs. Today mark day 27 of my exposure. Is it conclusive if I take the combo test today? Pls do reply me. Thank you very much.

    • Yes it will be conclusive. However, you might as well wait one more day to make it official.

  8. Dear doctors,

    Abbott AxSYM combo test at 40 days post exposure of receiving unprotected oral sex and frottage ( rubbing of genital with condom )

    Indicative or conclusive?

  9. Dear Dr Tan
    Regards to you.
    Please Help me.
    I am freaking out.
    I Had sex with a high class escort. During the intercourse the condom broke in between I noticed it and replaced it within 1-2 seconds. The girl confirmed to me that she was healthy. Got tested for HIV 1/2 & P-24(CMIA) combo test after 32 days of exposure which came negative. Had a rapid test at 58 days which also came negative. Again had a HIV 1/2 & P-24(CMIA) combo test after 66 days which also came negative. Do I need to go for further testing. Was worried as I found myself weighing 2-3 kg lesser which I know could be because of tense days I had. Kindly help. Shall be greatful to you.
    Regards.

    • Hi Neil,

      You needn’t worry. Your tests at 32 and 66 days show conclusively you do not have HIV. You don’t need any more further tests in my opinion.

      • Thanks for the cheering reply dear dr.
        Just wanted to ask ad to What could be the reasons for weight loss.
        I know I am troubling you, but if you could tell me about it.

        Regards & Thanks in anticipation.

        • It could be just normal variation or weight loss due to stress/ anxiety. See a doctor if the weight loss continues to persist.

          • Got blood sugar tests done today.
            Reports day 68-80.
            I hope that’s normal.
            Regards

  10. Hi Dr Tan,

    I took this test (as described below) from Gribbles 48 days after possible exposure and both p24 antigen and hiv 1/2 antibody shows negative. The doctor adviced to retest every 3 months for 1 year. How accurate is it at 48 days? My other exposures are 3 months, 4 months and 6 months respectively (Total only 4 possible exposures in my life).

    HIV Ag/Ab Screening Assay
    The HIV screening assay performed by Gribbles Pathology is known as a “combo” assay. It detects not only antibodies to HIV which are generally produced 3 to 4 weeks after exposure, but also p24 antigen which can be present in detectable amounts at 2 weeks post exposure. This combination enables detection of an infected individual at the earliest possible moment by minimising the “window period” between infection and detection.

  11. Hi Dr.
    I had a possible exposure at least 7 years ago and I just got the antigen and antibody for HIV1/2 done and the tests came back negative. I read that the antigen levels drop after 4 weeks so is this test conclusive in my case? If not what other tests can I take?

  12. worried

    Sorry I forgot to add. I was not give pep because the girl tested negative.am not native english speaker sorry That is my persol best

  13. worried

    Hi doc

    Doc, I had sexual exposure on 29th july 2014. I used condom that broke. My partner was sex worker. After the accident I persuaded the girl to take a test. After paying her extra money she agreed. We had antibody test and all came negative.after 13 days I developed joint pains and got scared. After testing I become negative. That night I did not sleep. Then came bad sore throat that after taking antibioticts and anti inflamatory didnt disappear. Doctor changed my medication after eight days to azthromycin and anti allergy. I have red patch in my mouth. I have fever that is mild not burning fever. I have red patche on my inner thigh with whitish scales, spreading to my leg. I have fine rash on th face. I have burning kidney whch after doing urine result are negative.
    Yesterday I did alere determine combo test. Result negative
    Unigold antibody test. Result negative.
    Please doctor am really scared to death. Normally am healthy person who does not get this scary signs and symptom.

  14. Hi Dr.

    I would appreciate if you could give me some insights on my situation. Had a baseline test 9 days after possible exposure – negative. 3 weeks after exposure started having minor cold symptoms (fever 37.1 C, weight loss more than 5 lbs and sore throat) Went for another test in 22th day after the exposure (while having symptoms) again negative. I asked about the test they use, doc said that it is 4th generation. I read that this test is accurate as early as early as 3-4 weeks. But doc said that it is only 50% accurate at 3 weeks. I will go for another test at 6 weeks mark and 3 month for sure. But she also claims that at 6 weeks it is 75% accurate only.
    I would really appreciate your thoughts on the test accuracy to have a piece of mind. Also is it possible that the test might be 4th generation but not combo ( only antibody)

    Thank you in advance

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